Additional concepts entail whether we lose significant numbers of neurons with normal aging, whether chronic alcohol abuse contributes to cortical neuron loss, whether there are significant differences in the quantitative composition of cerebral cortex between male and female brains, whether superior intelligence in humans correlates with larger numbers of brain cells, and whether there are secular (generational) changes in neuron number. This includes claims of how many cells compose the human brain, and how different cell types contribute and in what ratios. Here, I examine the history and current status of some of the most influential notions. Not all of the concepts that emerged from quantitative studies have turned out to be true. Over the last 50 years, quantitative methodology has made important contributions to our understanding of the cellular composition of the human brain.
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